2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase explained

2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase
Ec Number:	1.1.1.126
Cas Number:	37250-55-8
Go Code:	0047000

In enzymology, a 2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase is an enzyme that catalyzes the chemical reaction

2-dehydro-3-deoxy-D-gluconate + NADP⁺

\rightleftharpoons (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + NADPH + H⁺

Thus, the two substrates of this enzyme are 2-dehydro-3-deoxy-D-gluconate and NADP⁺, whereas its 3 products are (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 2-dehydro-3-deoxy-D-gluconate:NADP⁺ 6-oxidoreductase. Other names in common use include 2-keto-3-deoxy-D-gluconate dehydrogenase, and 2-keto-3-deoxygluconate dehydrogenase.

References

• Preiss J, Ashwell G . Alginic acid metabolism in bacteria. II. The enzymatic reduction of 4-deoxy-L-erythro-5-hexoseulose uronic acid to 2-keto-3-deoxy-D-gluconic acid . The Journal of Biological Chemistry . 237 . 317–21 . February 1962 . 14488585 .