2-Aminomuconate deaminase explained

2-aminomuconate deaminase
Ec Number:	3.5.99.5
Go Code:	0050540

In enzymology, 2-aminomuconate deaminase (also known as amnd) is an enzyme that catalyzes the chemical reaction

2-aminomuconate + H₂O

\rightleftharpoons 4-oxalocrotonate + NH₃

Thus, the two substrates of this enzyme are 2-aminomuconate and H₂O, whereas its two products are 4-oxalocrotonate and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in compounds that have not been otherwise categorized within EC number 3.5. The systematic name of this enzyme class is 2-aminomuconate aminohydrolase. This enzyme participates in tryptophan metabolism.

References

• He Z, Spain JC . 1998 . A novel 2-aminomuconate deaminase in the nitrobenzene degradation pathway of Pseudomonas pseudoalcaligenes JS45 . J. Bacteriol. . 180 . 2502 - 6 . 9573204 . 9 . 107194 .
• He Z, Spain JC . 1997 . Studies of the catabolic pathway of degradation of nitrobenzene by Pseudomonas pseudoalcaligenes JS45: removal of the amino group from 2-aminomuconic semialdehyde . Appl. Environ. Microbiol. . 63 . 4839 - 43 . 9471964 . 12 . 168809 .