2-Aminoindane Explained

2-Aminoindane (2-AI) is a research chemical with applications in neurologic disorders and psychotherapy that has also been sold as a designer drug.[1] It acts as a selective substrate for NET and DAT.[2] [3]

Therapeutic and illicit uses

Synthetic aminoindanes were originally developed in the context of anti-Parkinsonian drugs as a metabolite of rasagiline and as a tool to be used in psychotherapy. Deaths related to their toxic effects have been observed both in the laboratory in animal studies and in clinical encounters.[4] 2-AI is a rigid analogue of amphetamine and partially substitutes for it in rat discrimination tests.[5]

Chemical derivatives

There are a number of derivatives of 2-aminoindane and its positional isomer 1-aminoindane exist, including:

Legal status

China

As of October 2015 2-AI is a controlled substance in China.[6]

Sweden

Sweden's public health agency suggested classifying 2-AI as a hazardous substance, on June 24, 2019.[7]

United States

2-Aminoindane is not scheduled at the federal level in the United States,[8] but may be considered an analog of amphetamine, in which case purchase, sale, or possession could be prosecuted under the Federal Analog Act.

See also

Notes and References

  1. Manier SK, Felske C, Eckstein N, Meyer MR . The metabolic fate of two new psychoactive substances - 2-aminoindane and N-methyl-2-aminoindane - studied in vitro and in vivo to support drug testing . Drug Testing and Analysis . October 2019 . 12 . 1 . 145–151 . 31667988 . 10.1002/dta.2699 . free .
  2. Halberstadt AL, Brandt SD, Walther D, Baumann MH . 2-adrenergic receptors . Psychopharmacology . 236 . 3 . 989–999 . March 2019 . 30904940 . 6848746 . 10.1007/s00213-019-05207-1 .
  3. Simmler LD, Rickli A, Schramm Y, Hoener MC, Liechti ME . Pharmacological profiles of aminoindanes, piperazines, and pipradrol derivatives . Biochemical Pharmacology . 88 . 2 . 237–44 . March 2014 . 24486525 . 10.1016/j.bcp.2014.01.024 .
  4. Pinterova N, Horsley RR, Palenicek T . Synthetic Aminoindanes: A Summary of Existing Knowledge . Frontiers in Psychiatry . 8 . 236 . 2017 . 29204127 . 5698283 . 10.3389/fpsyt.2017.00236 . free .
  5. Oberlender R, Nichols DE . Structural variation and (+)-amphetamine-like discriminative stimulus properties . Pharmacology, Biochemistry, and Behavior . 38 . 3 . 581–6 . March 1991 . 2068194 . 10.1016/0091-3057(91)90017-V . 19069907 .
  6. Web site: 关于印发《非药用类麻醉药品和精神药品列管办法》的通知 . On the issuance of non-pharmaceutical narcotic drugs and psychotropic substances listed in the notice. China Food and Drug Administration . 27 September 2015 . Chinese . 1 October 2015 . https://web.archive.org/web/20151001222554/http://www.sfda.gov.cn/WS01/CL0056/130753.html . 1 October 2015 . dead .
  7. Web site: Åtta ämnen föreslås klassas som narkotika eller hälsofarlig vara . Eight substances are proposed to be classified as narcotics or dangerous to health. Folkhälsomyndigheten . sv . 24 June 2019 .
  8. Web site: 21 CFR — SCHEDULES OF CONTROLLED SUBSTANCES §1308.11 Schedule I. . 2018-02-14 . 2009-08-27 . https://web.archive.org/web/20090827043725/http://www.deadiversion.usdoj.gov/21cfr/cfr/1308/1308_11.htm . dead .

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