2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase explained

2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase
Ec Number:3.5.1.102

2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase (ArfB) is an enzyme with systematic name 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one amidohydrolase.[1] This enzyme catalyses the following chemical reaction

2-Amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O

\rightleftharpoons

2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + formate

The enzyme catalyses the second step in archaeal riboflavin and 7,8-didemethyl-8-hydroxy-5-deazariboflavin biosynthesis.

Notes and References

  1. Grochowski LL, Xu H, White RH . An iron(II) dependent formamide hydrolase catalyzes the second step in the archaeal biosynthetic pathway to riboflavin and 7,8-didemethyl-8-hydroxy-5-deazariboflavin . Biochemistry . 48 . 19 . 4181–8 . May 2009 . 19309161 . 10.1021/bi802341p .

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2025, A B Cryer, All Rights Reserved. Cookie policy.