2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase explained

2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
Ec Number:	2.2.1.10

2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase (ADH synthase, ADHS, MJ0400 (gene)) is an enzyme with systematic name L-aspartate 4-semialdehyde:1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate methylglyoxaltransferase.^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

L-aspartate 4-semialdehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate

\rightleftharpoons 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + 2,3-dioxopropyl phosphate

The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate.

Notes and References

1. White RH . L-Aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the precursors to the aromatic amino acids in Methanocaldococcus jannaschii . Biochemistry . 43 . 23 . 7618–27 . June 2004 . 15182204 . 10.1021/bi0495127 .
2. Samland AK, Wang M, Sprenger GA . MJ0400 from Methanocaldococcus jannaschii exhibits fructose-1,6-bisphosphate aldolase activity . FEMS Microbiology Letters . 281 . 1 . 36–41 . April 2008 . 18318840 . 10.1111/j.1574-6968.2008.01079.x . free .
3. Morar M, White RH, Ealick SE . Structure of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid synthase, a catalyst in the archaeal pathway for the biosynthesis of aromatic amino acids . Biochemistry . 46 . 37 . 10562–71 . September 2007 . 17713928 . 10.1021/bi700934v .