2-alkyn-1-ol dehydrogenase explained

2-alkyn-1-ol dehydrogenase
Ec Number:	1.1.1.165
Cas Number:	54576-94-2
Go Code:	0047535

In enzymology, a 2-alkyn-1-ol dehydrogenase is an enzyme that catalyzes the chemical reaction below:

2-butyne-1,4-diol + NAD⁺

\rightleftharpoons 4-hydroxy-2-butynal + NADH + H⁺

The two substrates of this enzyme are 2-butyne-1,4-diol and NAD⁺, whereas its 3 products are 4-hydroxy-2-butynal, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 2-butyne-1,4-diol:NAD⁺ 1-oxidoreductase.^[1]

Notes and References

1. Miyoshi T, Sato H, Harada T . 1974-08-26. Purification and characterization of 2-alkyne-1-ol dehydrogenase induced by 2-butyne-1,4-diol in Fusarium merismoides B11 . Biochimica et Biophysica Acta (BBA) - Enzymology. en. 358. 2. 231–239. 10.1016/0005-2744(74)90452-5. 0005-2744.