2-alkenal reductase explained

2-alkenal reductase
Ec Number:	1.3.1.74
Cas Number:	9032-20-6
Go Code:	0032440
Width:	270

In enzymology, a 2-alkenal reductase is an enzyme that catalyzes the chemical reaction

n-alkanal + NAD(P)+

\rightleftharpoons alk-2-enal + NAD(P)H + H⁺

The 3 substrates of this enzyme are n-alkanal, NAD⁺, and NADP⁺, whereas its 4 products are alk-2-enal, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is n-alkanal:NAD(P)+ 2-oxidoreductase. Other names in common use include NAD(P)H-dependent alkenal/one oxidoreductase, and NADPH:2-alkenal alpha,beta-hydrogenase.

Structural studies

As of late 2007, three structures have been solved for this class of enzymes, with PDB accession codes,, and .

References

• Mano J, Torii Y, ((Hayashi S-I)) . etal . 2002 . The NADPH:quinone oxidoreductase P1-zeta-crystallin in Arabidopsis catalyzes the alpha,beta-hydrogenation of 2-alkenals: detoxication of the lipid peroxide-derived reactive aldehydes . Plant Cell Physiol. . 43 . 1445 - 55 . 12514241 . 10.1093/pcp/pcf187 . 12 . free .
• Dick RA, Kwak MK, Sutter TR, Kensler TW . 2001 . Antioxidative function and substrate specificity of NAD(P)H-dependent alkenal/one oxidoreductase. A new role for leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase . J. Biol. Chem. . 276 . 40803 - 10 . 11524419 . 10.1074/jbc.M105487200 . 44 . free .