2-Picolylamine Explained

2-Picolylamine is an organic compound with the formula H2NCH2C5H4N. A colorless liquid, it is a common bidentate ligand and a precursor to more complex multidentate ligands such as tris(2-pyridylmethyl)amine. It is usually prepared by hydrogenation of 2-cyanopyridine. One such complex is Baratta's catalyst RuCl2(PPh3)2(ampy) (ampy = 2-picolylamine) for transfer hydrogenation.[1] Salts of the complex [Fe(pyCH<sub>2</sub>NH<sub>2</sub>)<sub>3</sub>]2+ exhibit spin crossover behavior, whereby the complex switches from high to low spin configurations, depending on the temperature.[2]

Safety

The oral in quail is low, being 750 mg/kg.

References

  1. 10.1016/j.ccr.2015.04.007. Ruthenium and Osmium Complexes Containing 2-(aminomethyl)pyridine (Ampy)-Based Ligands in Catalysis. Coordination Chemistry Reviews. 300. 29–85. 2015. Chelucci. Giorgio. Baldino. Salvatore. Baratta. Walter. 2318/1693450. free.
  2. 10.1016/S0010-8545(01)00381-2. Photoswitchable Coordination Compounds. Coordination Chemistry Reviews. 219. 839–879. 2001. Gütlich. P..