2-Oxohistidine Explained

2-Oxohistidine is a derivative of histidine damaged by reactive oxygen species. It is a biological marker for assessing protein modifications from oxidative stress.[1] In particular, it arises by iron-catalyzed reaction with hydrogen peroxide.[2]

Notes and References

  1. 8405458 . 2-Oxo-histidine as a novel biological marker for oxidatively modified proteins . FEBS Lett . 1993 . 332 . 3 . 208–210 . Uchida K, Kawakishi S . 10.1016/0014-5793(93)80632-5. free . 1993FEBSL.332..208U .
  2. 10.1038/nature04537 . The PerR transcription factor senses H2O2 by metal-catalysed histidine oxidation . 2006 . Lee . Jin-Won . Helmann . John D. . Nature . 440 . 7082 . 363–367 . 16541078 .

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