2-Methyl-MDA explained

2-Methyl-3,4-methylenedioxyamphetamine (2-methyl-MDA) is an entactogen and psychedelic drug of the amphetamine class. It acts as a selective serotonin releasing agent (SSRA), with IC₅₀ values of 93nM, 12,000nM, and 1,937nM for serotonin, dopamine, and norepinephrine efflux.^[1] 2-Methyl-MDA is more potent than MDA and 5-methyl-MDA. However, it is slightly more selective for serotonin over dopamine and norepinephrine release in comparison to 5-methyl-MDA.

Notes and References

1. Parker MA, Marona-Lewicka D, Kurrasch D, Shulgin AT, Nichols DE . Synthesis and pharmacological evaluation of ring-methylated derivatives of 3,4-(methylenedioxy)amphetamine (MDA) . Journal of Medicinal Chemistry . 41 . 6 . 1001–5 . March 1998 . 9526575 . 10.1021/jm9705925. 10.1.1.688.9559 .