2-Methoxyestriol Explained

2-Methoxyestriol should not be confused with 2-Methoxyestradiol.

2-Methoxyestriol (2-MeO-E3) is an endogenous estrogen metabolite.^{[1] [2] [3]} It is specifically a metabolite of estriol and 2-hydroxyestriol. It has negligible affinity for the estrogen receptors and no estrogenic activity.^[4] However, 2-methoxyestriol does have some non-estrogen receptor-mediated cholesterol-lowering effects.^[5]

See also

• 2-Methoxyestradiol
• 2-Methoxyestrone
• 4-Methoxyestradiol
• 4-Methoxyestrone

Notes and References

1. Fishman J, Gallagher TF . 2-Methoxyestriol: a new metabolite of estradiol in man . Arch. Biochem. Biophys. . 77 . 2 . 511–3 . October 1958 . 13584013 . 10.1016/0003-9861(58)90097-3 .
2. King RJ . Oestriol metabolism by rat- and rabbit-liver slices. Isolation of 2-methoxyoestriol and 2-hydroxyestriol . Biochem. J. . 79 . 2. 355–61 . May 1961 . 13756104 . 1205847 . 10.1042/bj0790355 .
3. Fujii Y, Teranishi M, Nakada K, Yamazaki M, Kishida S, Miyabo S . Radioimmunoassay of 2-methoxyestriol in pregnancy plasma . Horm. Metab. Res. . 20 . 9 . 599–600 . September 1988 . 3198067 . 10.1055/s-2007-1010895 . 260170130 .
4. Martucci CP . The role of 2-methoxyestrone in estrogen action . J. Steroid Biochem. . 19 . 1B . 635–8 . July 1983 . 6310247 . 10.1016/0022-4731(83)90229-7 .
5. Kono . Shinzo . Higa . Hiroaki . Sunagawa . Hajime . Hypocholesterolemic Effect of Long-Term Continuous Administration of 2-Methoxyestriol in Dietary Hypercholesterolemic Rats. Journal of Clinical Biochemistry and Nutrition . 6 . 1 . 1989 . 49–56 . 1880-5086 . 10.3164/jcbn.6.49 . free.