2-Hydroxy-5-methoxybenzaldehyde explained

2-Hydroxy-5-methoxybenzaldehyde is an organic compound and an isomer of vanillin.

Synthesis and reactions

The chemical is produced by the Reimer-Tiemann reaction on 4-methoxyphenol with a 79% yield.[1]

It reacts with malononitrile to form 2-imino-6-methoxy-2H-1-benzopyran-3-carbonitrile.[2] It can be reduced by sodium borohydride in ethanol to form 2-hydroxy-5-methoxybenzyl alcohol.[3]

See also

Notes and References

  1. Book: Wynberg. Hans. Meijer. Egbert W.. The Reimer–Tiemann Reaction. 2005. 16. 10.1002/0471264180.or028.01. 9780471264187.
  2. Dinparast. Leila. Hemmati. Salar. Zengin. Gokhan. Alizadeh. Ali Akbar. Bahadori. Mir Babak. Kafil. Hossein Samadi. Dastmalchi. Siavoush. Rapid, Efficient, and Green Synthesis of Coumarin Derivatives via Knoevenagel Condensation and Investigating Their Biological Effects. ChemistrySelect. 4. 31. 2019. 9211–9215. 2365-6549. 10.1002/slct.201901921. 202077668 .
  3. Cheng. Yan. Ono. Masahiro. Kimura. Hiroyuki. Kagawa. Shinya. Nishii. Ryuichi. Kawashima. Hidekazu. Saji. Hideo. Fluorinated Benzofuran Derivatives for PET Imaging of β-Amyloid Plaques in Alzheimer's Disease Brains. ACS Medicinal Chemistry Letters. 1. 7. 2010. 321–325. 1948-5875. 10.1021/ml100082x. 24900214 . 4007906.

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