2-Ethylhexyl diphenyl phosphate explained

2-Ethylhexyl diphenyl phosphate (Octicizer) is an organophosphate compound. It acts as both a plasticizer and flame retardant in PVC, its wide liquid range also makes it suitable as a flame retardant in hydraulic fluids. It has low acute toxicity in feeding experiments,^[1] but has been implicated as a potential hormone mimetic.^{[2] [3]}

Notes and References

1. Treon JF, Dutra FR, Cleveland FP . Toxicity of 2-ethylhexyl diphenyl phosphate. I. Immediate toxicity and effects of long-term feeding experiments . A.M.A. Archives of Industrial Hygiene and Occupational Medicine . 8 . 2 . 170–84 . August 1953 . 13064875 .
2. Li J, Zhao L, Letcher RJ, Zhang Y, Jian K, Zhang J, Su G . A review on organophosphate Ester (OPE) flame retardants and plasticizers in foodstuffs: Levels, distribution, human dietary exposure, and future directions . Environment International . 127 . 35–51 . June 2019 . 30901640 . 10.1016/j.envint.2019.03.009 . free . 2019EnInt.127...35L .
3. Li Y, Kang Q, Chen R, He J, Liu L, Wang L, Hu J . 2-Ethylhexyl Diphenyl Phosphate and Its Hydroxylated Metabolites are Anti-androgenic and Cause Adverse Reproductive Outcomes in Male Japanese Medaka (Oryzias latipes) . Environmental Science & Technology . 54 . 14 . 8919–8925 . July 2020 . 32559385 . 10.1021/acs.est.0c02775 . 2020EnST...54.8919L . 219948553 .