2-Deoxy-scyllo-inosamine dehydrogenase (SAM-dependent) explained
| 2-deoxy-scyllo-inosamine dehydrogenase (SAM-dependent) |
| Ec Number: | 1.1.99.38 |
2-deoxy-scyllo-inosamine dehydrogenase (SAM-dependent) ( (gene)) is an enzyme with systematic name 2-deoxy-scyllo-inosamine:S-adenosyl-L-methionine 1-oxidoreductase.[1] [2] This enzyme catalyses the following chemical reaction
3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + L-methionine
This enzyme participates in the biosynthetic pathway of the aminoglycoside antibiotics of the butirosin family.
Notes and References
- Yokoyama K, Numakura M, Kudo F, Ohmori D, Eguchi T . Characterization and mechanistic study of a radical SAM dehydrogenase in the biosynthesis of butirosin . Journal of the American Chemical Society . 129 . 49 . 15147–55 . December 2007 . 18001019 . 10.1021/ja072481t .
- Yokoyama K, Ohmori D, Kudo F, Eguchi T . Mechanistic study on the reaction of a radical SAM dehydrogenase BtrN by electron paramagnetic resonance spectroscopy . Biochemistry . 47 . 34 . 8950–60 . August 2008 . 18672902 . 10.1021/bi800509x .
