2-Deoxy-scyllo-inosamine dehydrogenase explained

2-deoxy-scyllo-inosamine dehydrogenase
Ec Number:1.1.1.329

2-deoxy-scyllo-inosamine dehydrogenase ( (gene name), kanK (gene name)) is an enzyme with systematic name 2-deoxy-scyllo-inosamine:NAD(P)+ 1-oxidoreductase.[1] [2] This enzyme catalyses the following chemical reaction

2-deoxy-scyllo-inosamine + NAD(P)+

\rightleftharpoons

3-amino-2,3-dideoxy-scyllo-inosose + NAD(P)H + H+

This enzyme requires zinc.

Notes and References

  1. Kudo F, Yamamoto Y, Yokoyama K, Eguchi T, Kakinuma K . Biosynthesis of 2-deoxystreptamine by three crucial enzymes in Streptomyces fradiae NBRC 12773 . The Journal of Antibiotics . 58 . 12 . 766–74 . December 2005 . 16506694 . 10.1038/ja.2005.104 . free .
  2. Nepal KK, Oh TJ, Sohng JK . Heterologous production of paromamine in Streptomyces lividans TK24 using kanamycin biosynthetic genes from Streptomyces kanamyceticus ATCC12853 . Molecules and Cells . 27 . 5 . 601–8 . May 2009 . 19466609 . 10.1007/s10059-009-0080-5 . free .

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