2-Benzylpiperidine Explained
2-Benzylpiperidine is a stimulant drug of the piperidine class. It is similar in structure to other drugs such as methylphenidate and desoxypipradrol but around one twentieth as potent, and while it boosts norepinephrine levels to around the same extent as d-amphetamine,[1] it has very little effect on dopamine levels, with its binding affinity for the dopamine transporter around 175 times lower than for the noradrenaline transporter.[2] 2-benzylpiperidine is little used as a stimulant, with its main use being as a synthetic intermediate in the manufacture of other drugs.[3] [4] [5]
See also
Notes and References
- Ferris RM, Tang FL . Comparison of the effects of the isomers of amphetamine, methylphenidate and deoxypipradrol on the uptake of l-[3H]norepinephrine and [3H]dopamine by synaptic vesicles from rat whole brain, striatum and hypothalamus . The Journal of Pharmacology and Experimental Therapeutics . 210 . 3 . 422–8 . September 1979 . 39160 .
- Kim DI, Deutsch HM, Ye X, Schweri MM . Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate . Journal of Medicinal Chemistry . 50 . 11 . 2718–31 . May 2007 . 17489581 . 10.1021/jm061354p .
- Ablordeppey SY, Fischer JB, Law H, Glennon RA . Probing the proposed phenyl-A region of the sigma-1 receptor . Bioorganic & Medicinal Chemistry . 10 . 8 . 2759–65 . August 2002 . 12057665 . 10.1016/S0968-0896(02)00096-2 .
- Ágai B, Proszenyák A, Tárkányi G, Vida L, Faigl F . Convenient, Benign and Scalable Synthesis of 2- and 4-Substituted Benzylpiperidines. . European Journal of Organic Chemistry . 2004 . 2004 . 17 . 3623–3632 . 10.1002/ejoc.200400215 .
- 2-substituted piperidine analogs and their use as subtype-selective NMDA receptor antagonists. . Bigge CF, Keana JR, Cai SX, Weber E, Woodward R, Lan NC, Guzikowski AP . US . 6124317 .
