2-Aminotetralin Explained

2-Aminotetralin (2-AT), also known as 1,2,3,4-tetrahydronaphthalen-2-amine (THN), is a stimulant drug with a chemical structure consisting of a tetralin group combined with an amine.^{[1] [2]}

2-AT is a rigid analogue of phenylisobutylamine and fully substitutes for d-amphetamine in rat discrimination tests, although at one eighth the potency. It has been shown to inhibit the reuptake of serotonin and norepinephrine, and likely induces their release as well.^{[3] [4]} It is also likely to act on dopamine on account of its full substitution of d-amphetamine in rodent studies.

Chemical derivatives

A number of derivatives of 2-aminotetralin exist, including:

See also

• 2-Aminodilin
• 2-Aminoindane

Notes and References

1. Oberlender R, Nichols DE . 19069907 . Structural variation and (+)-amphetamine-like discriminative stimulus properties . Pharmacology, Biochemistry, and Behavior . 38 . 3 . 581–6 . March 1991 . 2068194 . 10.1016/0091-3057(91)90017-V .
2. Marley E, Stephenson JD . Actions of dexamphetamine and amphetamine-like amines in chickens with brain transections . British Journal of Pharmacology . 42 . 4 . 522–42 . August 1971 . 5116035 . 1665761 . 10.1111/j.1476-5381.1971.tb07138.x .
3. Bruinvels J . Evidence for inhibition of the reuptake of 5-hydroxytryptamine and noradrenaline by tetrahydronaphthylamine in rat brain . British Journal of Pharmacology . 42 . 2 . 281–6 . June 1971 . 5091160 . 1667157 . 10.1111/j.1476-5381.1971.tb07109.x .
4. Bruinvels J, Kemper GC . Role of noradrenaline and 5-hydroxytryptamine in tetrahydronaphthylamine-induced temperature changes in the rat . British Journal of Pharmacology . 43 . 1 . 1–9 . September 1971 . 4257629 . 1665934 . 10.1111/j.1476-5381.1971.tb07151.x .