2-(S)-hydroxypropyl-CoM dehydrogenase explained

2-(S)-hydroxypropyl-CoM dehydrogenase
Ec Number:	1.1.1.269
Go Code:	0050575

In enzymology, a 2-(S)-hydroxypropyl-CoM dehydrogenase is an enzyme that catalyzes the chemical reaction

2-(S)-hydroxypropyl-CoM + NAD⁺

\rightleftharpoons 2-oxopropyl-CoM + NADH + H⁺

Thus, the two substrates of this enzyme are 2-(S)-hydroxypropyl-CoM and NAD⁺, whereas its 3 products are 2-oxopropyl-CoM, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 2-[2-(S)-hydroxypropylthio]ethanesulfonate:NAD⁺ oxidoreductase. This enzyme is also called 2-(2-(S)-hydroxypropylthio)ethanesulfonate dehydrogenase.

References

• Allen JR, Clark DD, Krum JG, Ensign SA . 1999 . A role for coenzyme M (2-mercaptoethanesulfonic acid) in a bacterial pathway of aliphatic epoxide carboxylation . Proc. Natl. Acad. Sci. U.S.A. . 96 . 8432 - 7 . 10411892 . 10.1073/pnas.96.15.8432 . 15 . 17533 . 1999PNAS...96.8432A . free .