| 2,5-dioxovalerate dehydrogenase | |
| Ec Number: | 1.2.1.26 |
| Cas Number: | 37250-92-3 |
| Go Code: | 0047533 |
In enzymology, a 2,5-dioxovalerate dehydrogenase is an enzyme that catalyzes the chemical reaction
2,5-dioxopentanoate + NADP+ + H2O
\rightleftharpoons
The 3 substrates of this enzyme are 2,5-dioxopentanoate, NADP+, and H2O, whereas its 3 products are 2-oxoglutarate, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2,5-dioxopentanoate:NADP+ 5-oxidoreductase. Other names in common use include 2-oxoglutarate semialdehyde dehydrogenase, and alpha-ketoglutaric semialdehyde dehydrogenase. This enzyme participates in ascorbate and aldarate metabolism.