2,5-dihydroxypyridine 5,6-dioxygenase explained
| 2,5-dihydroxypyridine 5,6-dioxygenase |
| Ec Number: | 1.13.11.9 |
| Cas Number: | 9029-57-6 |
| Go Code: | 0047075 |
In enzymology, a 2,5-dihydroxypyridine 5,6-dioxygenase is an enzyme that catalyzes the chemical reaction
2,5-dihydroxypyridine + O2
N-formylmaleamic acid
The 2 substrates of this enzyme are 2,5-dihydroxypyridine and O2, whereas its product is N-formylmaleamic acid.
This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2. It employs one cofactor, iron.
This enzyme participates in nicotinate and nicotinamide metabolism.[1]
Nomenclature
The systematic name of this enzyme class is 2,5-dihydroxypyridine:oxygen 5,6-oxidoreductase. Other names in common use include 2,5-dihydroxypyridine oxygenase, and pyridine-2,5-diol dioxygenase.
Further reading
- Behrman EJ, Stanier RY . 1957 . The bacterial oxidation of nicotinic acid . J. Biol. Chem. . 228 . 923 - 45 . 13475371 . 2 . 10.1016/S0021-9258(18)70671-6 . free .
- Gauthier JJ, Rittenberg SC . 1971 . The metabolism of nicotinic acid. I. Purification and properties of 2,5-dihydroxypyridine oxygenase from Pseudomonas putida N-9 . J. Biol. Chem. . 246 . 3737 - 42 . 5578917 . 11 . 10.1016/S0021-9258(18)62189-1 . free .
- Gauthier JJ, Rittenberg SC . 1971 . The metabolism of nicotinic acid. II. 2,5-dihydroxypyridine oxidation, product formation, and oxygen 18 incorporation . J. Biol. Chem. . 246 . 3743 - 8 . 5578918 . 11 . 10.1016/S0021-9258(18)62190-8 . free .
- Behrman EJ . N-Formylmaleamic acid: an intermediate in nicotinic acid metabolism . Proc. Natl. Acad. Sci. U.S.A. . 105 . 47 . E88; author reply E89 . November 2008 . 19020104 . 2587544 . 10.1073/pnas.0808695105 . 2008PNAS..105E..88B . free .
Notes and References
- Henke. Matthew T.. Snider. Mark J.. Mechanistic studies of 2,5-dihydroxypyridine 5,6-dioxygenase (NicX) from Bordetella bronchiseptica. The FASEB Journal. 1 April 2011. 25. 1 Supplement. 714.2. 13 February 2017. en. 0892-6638. 10.1096/fasebj.25.1_supplement.714.2. 31 January 2024. free .
