2,4-diaminopentanoate dehydrogenase explained

2,4-diaminopentanoate dehydrogenase
Ec Number:	1.4.1.12
Cas Number:	39346-26-4
Go Code:	0047530

In enzymology, a 2,4-diaminopentanoate dehydrogenase is an enzyme that catalyzes the chemical reaction

2,4-diaminopentanoate + H₂O + NAD(P)+

\rightleftharpoons 2-amino-4-oxopentanoate + NH₃ + NAD(P)H + H⁺

The 4 substrates of this enzyme are 2,4-diaminopentanoate, H₂O, NAD⁺, and NADP⁺, whereas its 5 products are 2-amino-4-oxopentanoate, NH₃, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2,4-diaminopentanoate:NAD(P)+ oxidoreductase (deaminating). This enzyme is also called 2,4-diaminopentanoic acid C4 dehydrogenase. This enzyme participates in 3 metabolic pathways: lysine degradation, arginine and proline metabolism, and d-arginine and d-ornithine metabolism.

References

• Somack R, Costilow RN . 1973 . 2,4-diaminopentanoic acid C 4 dehydrogenase. Purification and properties of the protein . J. Biol. Chem. . 248 . 385 - 8 . 4684685 . 2 .
• Stadtman TC . 1973 . Lysine metabolism by clostridia. XIIB 2,4-Diaminohexanoate dehydrogenase (2,4-diaminopentanoate dehydrogenase) . Adv. Enzymol. Relat. Areas Mol. Biol. . 38 . 441 - 445 .
• Tsuda Y, Friedmann HC . 1970 . Ornithine metabolism by Clostridium sticklandii. Oxidation of ornithine to 2-amino-4-ketopentanoic acid via 2,4-diaminopentanoic acid; participation of B12 coenzyme, pyridoxal phosphate, and pyridine nucleotide . J. Biol. Chem. . 245 . 5914 - 26 . 4394942 . 22 .