2,4'-dihydroxyacetophenone dioxygenase explained

2,4'-dihydroxyacetophenone dioxygenase
Ec Number:	1.13.11.41
Cas Number:	105503-64-8
Go Code:	0047073

In enzymology, a 2,4'-dihydroxyacetophenone dioxygenase is an enzyme that catalyzes the chemical reaction

2,4'-dihydroxyacetophenone + O₂

\rightleftharpoons 4-hydroxybenzoate + formate

Thus, the two substrates of this enzyme are 2,4'-dihydroxyacetophenone and O₂, whereas its two products are 4-hydroxybenzoate and formate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O₂. The systematic name of this enzyme class is 2,4'-dihydroxyacetophenone oxidoreductase (C-C-bond-cleaving). This enzyme is also called (4-hydroxybenzoyl)methanol oxygenase. This enzyme participates in bisphenol a degradation.^[1]

References

• Hopper DJ . Oxygenase properties of the (4-hydroxybenzoyl)methanol-cleavage enzyme from an Alcaligenes sp . The Biochemical Journal . 239 . 2 . 469–72 . October 1986 . 3814084 . 1147303 .

Notes and References

1. Enya M, Aoyagi K, Hishikawa Y, Yoshimura A, Mitsukura K, Maruyama K . Molecular and catalytic properties of 2,4'-dihydroxyacetophenone dioxygenase from Burkholderia sp. AZ11 . Bioscience, Biotechnology, and Biochemistry . 76 . 3 . 567–74 . 2012 . 22451401 . 10.1271/bbb.110867 . free .