2,2'-Dipyridyldisulfide Explained

2,2′-Dipyridyldisulfide, sometimes known as DPS, is used for preparing thiols^{[1] [2]} and activating carboxylic acid for coupling reactions, as in the following reaction:^[3]

Uses

It is also used in molecular biology as an oxidising agent, for example to oxidise free thiols to form disulfide bonds in proteins.

Notes and References

1. Futaki S. and Kitagawa K. . Peptide-Unit Assembling Using Disulfide Cross-Linking - a New Approach for Construction of Protein Models . 1994 . . 35 . 8 . 1267–1270 . 10.1016/0040-4039(94)88040-9.
2. . Special Reagents for Thiol Groups . 4 . 3 . 33–46.
3. . Thalmann A., Oertle K. and Gerlach H . Ricinelaidic acid lactone. 1985 . 7 . 470 . 10.15227/orgsyn.063.0192.