2,2'-Biphenol Explained

2,2′-Biphenol is an organic compound with the formula (C₆H₄OH)₂. It is one of three symmetrical isomers of biphenol. A white solid, it is a precursor to diphosphite ligands that are used to support industrial hydroformylation catalysis.^{[1] [2]} thumb|244px|left|BiPhePhos is representative diphosphite ligand derived from 2,2′-biphenol.

Synthesis

The chemical can be made by a hydrolysis reaction that opens the central ring of dibenzofuran. Alternatively, it can be produced from 2,4-di-tert-butylphenol in two steps. The first step entails oxidative coupling to give the 2,2′-biphenol with four tert-butyl substituents. This species then undergoes debutylation.

See also

• 1,1′-Bi-2-naphthol

References

1. 10.1021/ja00058a079. Practical, High-Yield, Regioselective, Rhodium-Catalyzed Hydroformylation of Functionalized α-Olefins. Journal of the American Chemical Society. 115. 2066–2068. 1993. Cuny. Gregory D.. Buchwald. Stephen L.. 5 .
2. 10.1021/OM950549K. Bulky Diphosphite-Modified Rhodium Catalysts: Hydroformylation and Characterization. Organometallics. 15. 835–847. 1996. Van Rooy. Annemiek. Kamer. Paul C. J.. Van Leeuwen. Piet W. N. M.. Goubitz. Kees. Fraanje. Jan. Veldman. Nora. Spek. Anthony L.. 2 .