2'-N-acetylparomamine deacetylase explained

2'-N-acetylparomamine deacetylase
Ec Number:	3.5.1.112

2'-N-acetylparomamine deacetylase (btrD (gene), neoL (gene), kanN (gene)) is an enzyme with systematic name 2'-N-acetylparomamine hydrolase (acetate-forming).^{[1] [2]} This enzyme catalyses the following chemical reaction

2'-N-acetylparomamine + H₂O

\rightleftharpoons paromamine + acetate

This enzyme takes part in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin.

Notes and References

1. Truman AW, Huang F, Llewellyn NM, Spencer JB . Characterization of the enzyme BtrD from Bacillus circulans and revision of its functional assignment in the biosynthesis of butirosin . Angewandte Chemie . 46 . 9 . 1462–4 . 2007 . 17226887 . 10.1002/anie.200604194 .
2. Yokoyama K, Yamamoto Y, Kudo F, Eguchi T . Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis . ChemBioChem . 9 . 6 . 865–9 . April 2008 . 18311744 . 10.1002/cbic.200700717 .