2'''-acetyl-6'''-hydroxyneomycin C deacetylase explained

2-acetyl-6-hydroxyneomycin C deacetylase
Ec Number:	3.5.1.113

2'''-acetyl-6'''-hydroxyneomycin C deacetylase (neoL (gene)) is an enzyme with systematic name 2'''-acetyl-6'''-hydroxyneomycin C hydrolase (acetate-forming).^[1] This enzyme catalyses the following chemical reaction

2'''-acetyl-6'''-deamino-6'''-hydroxyneomycin C + H₂O

\rightleftharpoons 6'''-deamino-6'''-hydroxyneomycin C + acetate

This enzyme is involved in biosynthesis of aminoglycoside antibiotics of the [neomycin] family.

Notes and References

1. Yokoyama K, Yamamoto Y, Kudo F, Eguchi T . Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis . ChemBioChem . 9 . 6 . 865–9 . April 2008 . 18311744 . 10.1002/cbic.200700717 .