| Year: | 1999 |
| Team: | Tennessee State Tigers |
| Sport: | football |
| Conference: | Ohio Valley Conference |
| Short Conf: | OVC |
| Record: | 11–1 |
| Conf Record: | 7–0 |
| Head Coach: | L. C. Cole |
| Hc Year: | 4th |
| Stadium: | Adelphia Coliseum |
| Champion: | OVC champion |
| Bowl Result: | L 10–24 at North Carolina A&T |
The 1999 Tennessee State Tigers football team represented Tennessee State University as a member of the Ohio Valley Conference (OVC) during the 1999 NCAA Division I-AA football season. Led by fourth-year head coach L. C. Cole, the Tigers compiled an overall record of 11–1, with a conference record of 7–0, and finished as OVC champion. Tennessee State was upset by North Carolina A&T in the first round of the NCAA Division I-AA playoffs.