The 1999 Swisscom Challenge was a women's tennis tournament played on indoor hard courts at the Schluefweg in Zurich, Switzerland that was part of Tier I of the 1999 WTA Tour. It was the 16th edition of the tournament and was held from 10 October until 17 October 1999. Second-seeded Venus Williams won the singles title.
| Country | Player | Rank | Seed | |
|---|---|---|---|---|
| Martina Hingis | 1 | 1 | ||
 United States | 3 | 2 | ||
 France | Mary Pierce | 6 | 3 | |
| Amanda Coetzer | 7 | 4 | ||
 Austria | 8 | 5 | ||
| France | 9 | 6 | ||
 Belgium | 10 | 7 | ||
| France | 11 | 8 |
The following players received wildcards into the singles main draw:
The following players received wildcards into the doubles main draw:
The following players received entry from the qualifying draw:
See main article: 1999 Swisscom Challenge – Singles qualifying.
The following player received entry as a lucky loser:
See main article: 1999 Swisscom Challenge – Singles. Venus Williams defeated Martina Hingis 6–3, 6–4
See main article: 1999 Swisscom Challenge – Doubles. Lisa Raymond / 
Rennae Stubbs defeated Nathalie Tauziat / 
Natasha Zvereva 6–2, 6–2
