| Year: | 1999 |
| Team: | SMU Mustangs |
| Sport: | football |
| Conference: | Western Athletic Conference |
| Short Conf: | WAC |
| Record: | 4–6 |
| Conf Record: | 3–3 |
| Head Coach: | Mike Cavan |
| Hc Year: | 3rd |
| Off Coach: | Greg Briner |
| Oc Year: | 2nd |
| Cooff Coach1: | Larry Kueck |
| Cooc1 Year: | 1st |
| Off Scheme: | Spread option |
| Def Coach: | Eric Schumann |
| Dc Year: | 3rd |
| Def Scheme: | 4–3 |
The 1999 SMU Mustangs football team represented Southern Methodist University (SMU) as a member the Western Athletic Conference (WAC) during the 1999 NCAA Division I-A football season. Led by third-year head coach Mike Cavan, the Mustangs compiled an overall record of 4–6 with a mark of 3–3 in conference play, placing fifth in the WAC.