The 1999 Italian Open was a tennis tournament played on outdoor clay courts. It was the 56th edition of the Italian Open, and was part of the ATP Super 9 of the 1999 ATP Tour, and of the Tier I Series of the 1999 WTA Tour. Both the men's and the women's events took place at the Foro Italico in Rome, Italy.
The men's field was led by ATP No. 2, Rotterdam, Australian Open titlist Yevgeny Kafelnikov, Wimbledon, Vienna winner, Paris runner-up Pete Sampras and Sydney champion, Masters Cup winner Àlex Corretja. Also competing were US Open defending champion Patrick Rafter, London titlist Richard Krajicek, Carlos Moyá, Tim Henman and Marcelo Ríos.
The women's draw was headlined by the WTA No. 1, Australian Open, Tokyo winner, and Sydney finalist Martina Hingis; the Cairo titlist, and Hamburg semi-finalist Arantxa Sánchez Vicario; and the Key Biscayne, Oklahoma, Hamburg champion Venus Williams. Other top seeds were Gold Coast runner-up Mary Pierce, Gold Coast champion Patty Schnyder, Indian Wells champion Serena Williams, and Frenchwomen Nathalie Tauziat and Sandrine Testud.
| Country | Player | Rank | Seed |
|---|---|---|---|
| 1 | 1 | ||
 Spain | 7 | 2 | |
 United States | Venus Williams | 5 | 3 |
 France | 8 | 4 | |
| 12 | 5 | ||
| United States | 10 | 6 | |
| France | 9 | 7 | |
| France | Sandrine Testud | 11 | 8 |
 Russian Federation | 13 | 9 | |
| France | Amélie Mauresmo | 16 | 10 |
 Belgium | Dominique Van Roost | 15 | 11 |
| Amanda Coetzer | 14 | 12 | |
 Romania | Irina Spîrlea | 17 | 13 |
 Belarus | Natasha Zvereva | 19 | 14 |
| Spain | Conchita Martínez | 18 | 15 |
| Russian Federation | Elena Likhovtseva | 22 | 16 |
The following players received wildcards into the singles main draw:
The following players received wildcards into the doubles main draw:
The following players received entry from the singles qualifying draw:
Francesca Schiavone
María Vento Sabine Appelmans Elena Dementieva Antonella Serra Zanetti Germana Di Natale Sandra CacicThe following player received entry as a lucky loser:
The following players received entry from the doubles qualifying draw:
The following players received entry as lucky losers:
See main article: 1999 Italian Open – Men's singles. 
Gustavo Kuerten defeated 
Patrick Rafter, 6–4, 7–5, 7–6(8–6).[1]
See main article: 1999 Italian Open – Women's singles. Venus Williams defeated Mary Pierce, 6–4, 6–2.[2]
See main article: 1999 Italian Open – Men's doubles. Ellis Ferreira / Rick Leach defeated David Adams / John-Laffnie de Jager, 6–7, 6–1, 6–2.[1]
See main article: 1999 Italian Open – Women's doubles. Martina Hingis / Anna Kournikova defeated Alexandra Fusai / Nathalie Tauziat, 6–2, 6–2.[2]