| Club: | LDU Quito |
| Season: | 1999 |
| Chairman: | Darío Ávila |
| Chrtitle: | President |
| Manager: | Manuel Pellegrini |
| Mgrtitle: | Manager |
| Stadium: | Estadio Casa Blanca |
| League: | Serie A |
| League Result: | Champions (6th title) |
| Cup1: | Copa Libertadores |
| Cup1 Result: | Round of 16 |
| League Topscorer: | Ezequiel Maggiolo (14 goals) |
| Season Topscorer: | Ezequiel Maggiolo (15 goals) |
| Pattern La1: | _LDU 1999 |
| Pattern B1: | _LDU 1999 |
| Pattern Ra1: | _LDU 1999 |
| Pattern Sh1: | _LDU 1999 |
| Pattern So1: | _LDU 1999 |
| Pattern La2: | _LDU 1999a |
| Pattern B2: | _LDU 1999a |
| Pattern Ra2: | _LDU 1999a |
| Pattern Sh2: | _LDU 1999 AWAY |
| Pattern So2: | _red_midband_color |
| Socks2: | 000040 |
| Prevseason: | 1998 |
| Nextseason: | 2000 |
Liga Deportiva Universitaria de Quito's 1999 season was the club's 69th year of existence, the 46th year in professional football, and the 39th in the top level of professional football in Ecuador.
Supplier: Umbro
Sponsor(s): La Lechera, Crunch, Ecuatoriana
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See main article: article and 1999 Copa Libertadores.
River Plate and LDU Quito were tied on points and goal difference. River Plate advanced on penalty kicks.