| Year: | 1999 |
| Team: | Jackson State Tigers |
| Sport: | football |
| Conference: | Southwestern Athletic Conference |
| Short Conf: | SWAC |
| Division: | East Division |
| Record: | 9–3 |
| Conf Record: | 4–0 |
| Head Coach: | Judge Hughes |
| Hc Year: | 1st |
| Stadium: | Mississippi Veterans Memorial Stadium |
| Champion: | SWAC East Division champion |
| Conf Champ: | SWAC Championship Game |
| Conf Champ Result: | L 30–31 vs. Southern |
The 1999 Jackson State Tigers football team represented Jackson State University as a member of the Southwestern Athletic Conference (SWAC) during the 1999 NCAA Division I-AA football season. Led by first-year head coach Judge Hughes, the Tigers compiled an overall record of 9–3 and a mark of 4–0 in conference play, and finished first in the SWAC East Division. The Tigers ended their season with a loss against Southern in the SWAC Championship Game.