| Year: | 1999 |
| Team: | Iowa State Cyclones |
| Conference: | Big 12 Conference |
| Division: | North Division |
| Short Conf: | Big 12 |
| Record: | 4–7 |
| Conf Record: | 1–7 |
| Hc Year: | 5th |
| Oc Year: | 2nd |
| Dc Year: | 4th |
| Stadium: | Jack Trice Stadium |
The 1999 Iowa State Cyclones football team represented Iowa State University during the 1999 NCAA Division I-A football season. They played their home games at Jack Trice Stadium in Ames, Iowa. They participated as members of the Big 12 Conference in the North Division. The team was coached by head coach Dan McCarney.