The 1999 Grand Prix de Tennis de Lyon was a men's tennis tournament played on indoor carpet courts at the Palais des Sports de Gerland in Lyon, France, and was part of the International Series of the 1999 ATP Tour. It was the 13th edition of the tournament and was held from 18 October until 25 October 1999. Sixth-seeded Nicolás Lapentti won the singles title.
See main article: 1999 Grand Prix de Tennis de Lyon – Singles. 
Nicolás Lapentti defeated 
Lleyton Hewitt 6–3, 6–2
See main article: 1999 Grand Prix de Tennis de Lyon – Doubles. Piet Norval / Kevin Ullyett defeated Wayne Ferreira / Sandon Stolle 4–6, 7–6(7–5), 7–6(7–4)