The 1999 Family Circle Cup was a women's tennis tournament played on outdoor clay courts at the Sea Pines Plantation on Hilton Head Island, South Carolina in the United States that was part of Tier I of the 1999 WTA Tour. It was the 27th edition of the tournament and was held from March 29 through April 4, 1999. Martina Hingis won the singles title.
See main article: 1999 Family Circle Cup – Singles. Martina Hingis defeated 
Anna Kournikova, 6–4, 6–3
See main article: 1999 Family Circle Cup – Doubles. Elena Likhovtseva / 
Jana Novotná defeated 
Barbara Schett / Patty Schnyder, 6–1, 6–4
| Country | Player | Rank | Seed |
|---|---|---|---|
| 1 | 1 | ||
 United States | 3 | 2 | |
| Czech Republic | Jana Novotná | 4 | 3 |
 Spain | 7 | 4 | |
| 9 | 5 | ||
| 13 | 6 | ||
| Russian Federation | 20 | 7 | |
 France | Amélie Mauresmo | 14 | 8 |
 Romania | 15 | 9 | |
| Spain | Conchita Martínez | 18 | 10 |
 Belarus | Natasha Zvereva | 17 | 11 |
| Austria | Barbara Schett | 19 | 12 |
 Italy | Silvia Farina | 25 | 13 |
| Russian Federation | Elena Likhovtseva | 22 | 14 |
| Spain | Magüi Serna | 24 | 15 |
 Slovakia | Henrieta Nagyová | 26 | 16 |
The following players received wildcards into the singles main draw:
The following players received entry from the singles qualifying draw:
Paola Suárez Adriana Gerši Alexandra Stevenson Elena Makarova Tatiana Panova Lilia Osterloh Sandra CacicThe following players received entry as a lucky loser:
The following players received entry from the doubles qualifying draw:
