The women's 4 x 100 metres relay event at the 1999 European Athletics U23 Championships was held in Göteborg, Sweden, at Ullevi on 1 August 1999.
| Gold | Nadine Mahobah Muriel Hurtis Fabé Dia Doris Deruel  | |
| Silver | Alice Reuss Marion Wagner Esther Möller Sabrina Mulrain | |
| Bronze | Monika Długa Irena Sznajder Agnieszka Rysiukiewicz Magdalena Haszczyc  |
1 August
| Rank | Nation | Competitors | Time | Notes | ||
|---|---|---|---|---|---|---|
| align=left | | 43.39 | CR | |||
| align=left | 43.53 | |||||
| align=left | | 44.47 | ||||
| 4 | align=left |  | 44.55 | |||
| 5 | align=left |  | 44.86 | |||
| 6 | align=left |  | 45.28 | |||
| 7 | align=left |  | 45.47 |
According to an unofficial count, 28 athletes from 7 countries participated in the event.
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