| Year: | 1999 |
| Team: | Clemson Tigers |
| Conference: | Atlantic Coast Conference |
| Short Conf: | ACC |
| Record: | 6–6 |
| Conf Record: | 5–3 |
| Hc Year: | 1st |
| Oc Year: | 1st |
| Dc Year: | 1st |
| Captain2: | Ryan Romano |
| Captain3: | Brandon Streeter |
| Stadium: | Memorial Stadium (Capacity: 81,473) |
| Bowl Result: | L 7–17 vs. Mississippi State |
The 1999 Clemson Tigers football team represented Clemson University during the 1999 NCAA Division I-A football season.