See main article: 1999 Australian Open.
Mariaan de Swardt and David Adams defeated Serena Williams and Max Mirnyi in the final, 6–4, 4–6, 7–6(7–5) to win the mixed doubles tennis title at the 1999 Australian Open.
Venus Williams and Justin Gimelstob were the defending champions, but did not compete that year.
One of the surprises of this tournament was that over half of the seeds lost in the first round, and none of the seeds made it past the second round.