| Season: | 1999–2000 |
| Dates: | 12 August 1999 – 14 May 2000 |
| Winners: | PSV (15th title) |
| League Topscorer: |  Ruud van Nistelrooy (29 goals)[1] |
| Total Goals: | 997 |
| Average Goals: | 3.25 |
| Nextseason: | 2000–01 |
The Dutch Eredivisie in the 1999–2000 season was contested by 18 teams. PSV won the championship.
In the promotion/relegation competition, eight entrants (six from the Eerste Divisie and two from this league) entered in two groups. The group winners were promoted to (or remained in) the Eredivisie.
| Goals | Player | Team |
|---|---|---|
| Ruud van Nistelrooy | PSV | |
| Pierre van Hooijdonk | Vitesse Arnhem | |
| Arnold Bruggink | PSV | |
 Luc Nilis | PSV | |
| Jan Vennegoor of Hesselink | Twente | |
| John Bosman | AZ | |
| Anthony Lurling | Heerenveen | |
 Julio Cruz | Feyenoord | |
| Richard Knopper | Ajax | |
| Bob Peeters | Roda JC |
Source: worldfootball.net