| Season: | 1999–2000 |
| Matches: | 306 |
| Total Goals: | 805 |
| Nextseason: | 2000–01 |
The 1999–2000 season of the Slovak Second Football League (also known as 2. liga) was the seventh season of the league since its establishment. It began on 31 July 1999 and ended on 11 June 2000.