| Club: | PSV Eindhoven |
| Season: | 1999–2000 |
| Manager: | Eric Gerets |
| Mgrtitle: | Head coach |
| Stadium: | Philips Stadion |
| League: | Eredivisie |
| League Result: | 1st |
| Cup1: | KNVB Cup |
| Cup1 Result: | Round of 16 |
| Cup2: | Champions League |
| Cup2 Result: | Group stage |
| League Topscorer: | Ruud van Nistelrooy (29) |
| Season Topscorer: | Ruud van Nistelrooy (32) |
| Pattern La1: | _psv9800h |
| Pattern B1: | _psv9800h |
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| Pattern So1: | _redtop |
| Leftarm1: | FFFFFF |
| Body1: | FFFFFF |
| Rightarm1: | FFFFFF |
| Shorts1: | 000000 |
| Socks1: | FFFFFF |
| Pattern La2: | _psv9901a |
| Pattern B2: | _psv9901a |
| Pattern Ra2: | _psv9901a |
| Pattern Sh2: | _blacksides |
| Leftarm2: | 000000 |
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| Shorts2: | 3DBAFE |
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| Prevseason: | 1998–99 |
| Nextseason: | 2000–01 |
During the 1999–2000 Dutch football season, PSV Eindhoven competed in the Eredivisie.
PSV claimed the Eredivisie title with a margin of 16 points between them and second-placed Heerenveen, scoring 105 goals in the process.
PSV's kit was manufactured by Nike and sponsored by Philips
Squad at end of season
Eric Addo - 
Club Brugge, fl.5.9m Gilles De Bilde - Sheffield Wednesday, August