Martina Hingis defeated Venus Williams in the final, with a score of 6–3, 2–6, 6–3 to win the women's singles tennis title at the 1998 Italian Open.[1]
Mary Pierce was the defending champion, but lost in the third round to Mirjana Lučić.
A champion seed is indicated in bold text while text in italics indicates the round in which that seed was eliminated. The top eight seeds received a bye to the second round.