| Champ: |  Venus Williams Justin Gimelstob |
| Runner: | Serena Williams  Luis Lobo |
| Score: | 6–4, 6–4 |
| Seeds: | 16 |
See main article: 1998 French Open. Venus Williams and Justin Gimelstob defeated Serena Williams and Luis Lobo in the final, 6–4, 6–4 to win the mixed doubles tennis title at the 1998 French Open.
Rika Hiraki and Mahesh Bhupathi were the defending champions, but chose not to compete together. Hiraki played with Paul Kilderry and lost in the third round, while Bhupathi played with Rennae Stubbs and lost in the second round.
All seeds received a bye into the second round.