See main article: 1992 US Open (tennis).
Defending champion Monica Seles defeated Arantxa Sánchez Vicario in the final, 6–3, 6–3 to win the women's singles tennis title at the 1992 US Open. She did not lose a set during the tournament. By reaching the final, Seles became the sixth woman, after Maureen Connolly, Margaret Court, Chris Evert, Martina Navratilova, and Steffi Graf to reach all four major finals in a calendar year.
See main article: 1992 US Open – Women's singles qualifying.