| Year: | 1991 |
| Team: | Louisville Cardinals |
| Sport: | football |
| Conference: | Independent |
| Record: | 2–9 |
| Head Coach: | Howard Schnellenberger |
| Hc Year: | 7th |
| Off Coach: | Gary Nord |
| Oc Year: | 3rd |
| Def Coach: | Ty Smith |
| Dc Year: | 1st |
| Stadium: | Cardinal Stadium |
The 1991 Louisville Cardinals football team represented the University of Louisville as an independent during the 1991 NCAA Division I-A football season. Led by seventh-year head coach Howard Schnellenberger, the Cardinals compiled a record of 2–9. The team played their home games in Cardinal Stadium in Louisville, Kentucky.
The following Cardinal was selected in the 1992 NFL draft after the season.[2]
| 12 | 311 | Klaus Wilmsmeyer | Kicker | Tampa Bay Buccaneers |