| Year: | 1991 |
| Team: | Houston Cougars |
| Sport: | football |
| Conference: | Southwest Conference |
| Short Conf: | SWC |
| Record: | 4–7 |
| Conf Record: | 3–5 |
| Head Coach: | John Jenkins |
| Hc Year: | 2nd |
| Stadium: | Houston Astrodome |
The 1991 Houston Cougars football team represented the University of Houston as a member of the Southwest Conference (SWC) during the 1991 NCAA Division I-A football season. The Cougars were led by second-year head coach John Jenkins and played their home games at the Houston Astrodome in Houston, Texas. Houston compiled an overall record of 4–7 and a mark of 3–5 in conference play, placing seventh in the SWC.
See also: 1991 Miami Hurricanes football team.
The following Cougars were selected in the 1992 NFL draft after the season.[3]
| 1 | 6 | David Klingler | Quarterback | Cincinnati Bengals | |
| 6 | 154 | Glenn Cadrez | Linebacker | New York Jets | |
| 7 | 192 | John Brown | Wide receiver | Chicago Bears | |
| 9 | 226 | Ostell Miles | Running back | Cincinnati Bengals | |
| 11 | 303 | Mike Gisler | Defensive tackle | New Orleans Saints |