| Year: | 1991 |
| Team: | Eastern Illinois Panthers |
| Sport: | football |
| Conference: | Gateway Collegiate Athletic Conference |
| Short Conf: | GCAC |
| Record: | 4–7 |
| Conf Record: | 2–4 |
| Head Coach: | Bob Spoo |
| Hc Year: | 5th |
| Off Coach: | Roy Wittke |
| Oc Year: | 2nd |
| Stadium: | O'Brien Stadium |
The 1991 Eastern Illinois Panthers football team represented Eastern Illinois University as a member of the Gateway Collegiate Athletic Conference (GCAC) during the 1991 NCAA Division I-AA football season. Led by fifth-year head coach Bob Spoo, the Panthers played their home games at O'Brien Stadium in Charleston, Illinois. Eastern Illinois finished the season with on overall record of 4–7 and a conference mark of 2–4, tying for fifth place.