| Club: | Sampdoria |
| Season: | 1991–92 |
| Chairman: | Enrico Mantovani |
| Manager: | Vujadin Boškov |
| Stadium: | Stadio Luigi Ferraris |
| League: | Serie A |
| League Result: | 7th |
| League Topscorer: | Gianluca Vialli (11) |
| Season Topscorer: | Gianluca Vialli (20) |
| Cup1: | European Cup |
| Cup1 Result: | Runners-up |
| Cup2: | Coppa Italia |
| Cup2 Result: | Semi-final |
| Leftarm1: | 0044BE |
| Pattern B1: | _samp |
| Body1: | 0044BE |
| Rightarm1: | 0044BE |
| Shorts1: | FFFFFF |
| Socks1: | 0044BE |
| Pattern B2: | _samp |
| Body2: | FFFFFF |
| Leftarm2: | FFFFFF |
| Rightarm2: | FFFFFF |
| Shorts2: | 0044BE |
| Socks2: | FFFFFF |
| Prevseason: | 1990–91 |
| Nextseason: | 1992–93 |
The 1991–92 season saw Sampdoria compete in this season's editions of the Serie A, Coppa Italia, and European Cup. The club reached the 1992 European Cup Final only to suffer a 1–0 loss in extra time to Barcelona.
In the league, Sampdoria finished tied for sixth with Parma. Due to Sampdoria's failure to secure European football, championship-winning coach Vujadin Boškov left his job.
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See main article: 1991 Supercoppa Italiana.
See main article: 1991–92 Serie A.
See main article: 1991–92 Coppa Italia.
See main article: 1991–92 European Cup.
See main article: 1992 European Cup Final.