Stefan Edberg defeated Andre Agassi in the final, 6–4, 5–7, 7–6(7–1), 7–6(8–6) to win the men's singles tennis title at the 1990 Indian Wells Masters.
Miloslav Mečíř was the defending champion, but lost in the first round to Richey Reneberg.
The top eight seeds received a bye into the second round.
Stefan Edberg (champion)
Brad Gilbert (third round) Aaron Krickstein (quarterfinals) Andre Agassi (final) Tim Mayotte (second round) Jay Berger (quarterfinals) Mats Wilander (first round)
Martín Jaite (first round) Alberto Mancini (first round)
Andrés Gómez (first round) Pete Sampras (second round)
Emilio Sánchez (quarterfinals)
Horst Skoff (third round)