See main article: 1990 Lipton International Players Championships.
Andre Agassi defeated Stefan Edberg in the final, 6 - 1, 6 - 4, 0 - 6, 6 - 2 to win the men's singles tennis title at the 1990 Miami Open.
Ivan Lendl was the defending champion, but lost in the fourth round to Emilio Sánchez.
All seeds received a bye to the second round.